三氯苯达唑治疗斯氏狸殖吸虫病的初步观察

A Clinical Trial of Triclabendazole in the Treatment of Human Paragonimiasis skrjabini

目的 观察三氯苯达唑对人体斯氏狸殖吸虫病的治疗作用。 方法 用三氯苯达唑治疗 4例斯氏狸殖吸虫病患者 ,随访 6～ 10个月 ,观察患者的症状、体征和胸部X线表现及嗜酸性粒细胞等的变化情况。 结果 经治疗后 ,全部患者的症状如皮下游走性包块与体征及胸部X线表现 ,肺部浸润及胸腔积液均消失 ,嗜酸性粒细胞恢复正常。患者服药过程中及随访时均未出现任何不良反应。 结论 三氯苯达唑治疗斯氏狸殖吸虫病具有疗效好、疗程短、耐受性极好的优点。

Objective To observe the therapeutic effect of triclabendazole in patients with paragonimiasis skrjabini. Methods Four patients were treated with triclabendazole at dosage of 10 mg/kg bid for 3 days and were followed up for 6～10 months. The clinical symptoms, chest X ray, hemogram and liver function tests were observed before and after treatment. Results Migratory subcutaneous nodules in three patients all disappeared. Small amount of pleural effusion were absorbed in two patients. Severe headache subsided in a patient with cerebral lesion. MRI showed a bean sized calcified spot in the right frontal region. Chest X ray in 2 patients showed that pulmonary lesions were markedly absorbed and disappeared. There was no adverse effect of the drug.Conclusion Triclabendazole has marked therapeutic effect on paragonimiasis skrjabini. It is safe in administration and well tolerated.