国产三相避孕片对月经失调妇女血脂的影响

Triphasic Oral Contraceptive on the Lipid Metabolism of Patients with Menstrual Dysfunction

研究三相避孕片治疗功血及闭经等疾病对血脂的影响。患者按 2∶ 1随机分配为试验组 6 0例和对照组 32例。试验组用三相片 3周期 ,对照组 EE0 .0 3mg/日 ,连服 2 0天 ,自服 EE第 11天起序贯加用 MPA4mg Bid,连服 10天 ,共用 3周期。两组用药前及停药后测量血脂。结果功血患者血脂变化 TC及 L DL - C上升具有统计学意义 ,但均在正常范围内波动。无排卵型功血的血脂影响最小 ;CT/ HDL- C及 L DL- C/ HDL- C变化均无统计学意义。对闭经妇女 ,TC/HDL- C,L L- C/ HDL- C均上升 ,有显著性差异 ,亦在正常范围波动。提示三相避孕片作为治疗功血控制月经周期 ,对闭经作人工周期治疗等 ,对血脂代谢影是安全的 。

Objectives:This sluds is observed the changes of lipid meladolism of patients who had merstrdl dysfumcion trealed by triphaser and compave with those of convential sequential estrogen any progestion.Patients with menstrual dysfunction were assigned randomly 2:1 to two groups with 60 cases and 32 cases in experiment and control groups separately completing the therapy.With Three Cyles The experiment group took triphaser(one pill daily)21 days from the 3 rd day of menstrual cycle of freom the first visiting day of amenorrhea;the control group took EE(0.03mg daily)20 days with the later 10 days combined with MPA 4mg twice daily.Each group began the second treatment period on the 3rd day of withdrawal blleding and three months duration was needed.Triphaser had little clinical effects on the lipid metabolism of patients with dysfunctional uterine bleeding with increased TC and LDL C and no change of TG,HDL C,VLDL C,TC/HDL C,and LDL/ C/HDL C(TG decreased and LDL C/ HDL C increased in ovulational DUB patients).However,on patients with amenorrhea and perimenopause.Triphaser exerted and untoward effects with increased TC/HDL C and LDL C/HDL C besides the above changes in the other two types of patients.All the changes in lipid metabolism were within the normal range compared with those of control group and had no statistical significance.