颅脑损伤后血、脑脊液一氧化氮、内皮素含量变化及其临床意义

Clinical significance of the changes of NO and ET in blood and CSF in acute craniocerebral injury

目的 测定急性颅脑损伤患者血、脑脊液一氧化氮 (NO)、内皮素 (ET)含量 ,探讨它们在颅脑外伤中的作用机理。方法 测定 60例急性颅脑损伤患者血、脑脊液中NO、ET含量 ,按GCS评分分组 ,并与对照组比较。结果 全组病人伤后均出现血、脑脊液NO、ET含量显著升高 ,以重伤组 (GCS≤ 8分 )尤为明显 ,与对照组比较 ,差异显著 ,且以脑脊液中NO升高最为显著。结论 NO、ET参与了急性颅脑损伤后病理生理变化 ,监测它们的含量变化 。

Objective To study the role of NO and ET in acute craniocerebral injury by determination of the contents of NO and ET in the blood and CSF of the patients.?Methods Sixty cases with acute craniocerebral injury were divided into two groups by their GCS score.Contents of NO and ET in blood and CSF were determined,and compared to that of the control group.?Results The contents of NO and ET in blood and CSF of the two groups were higher than that of the controls,especially in GCS≤8 group.?Conclusion NO and ET play an important role in the pathologic and physiological courses,and have an important significance to the treatment and diagnosis of acute craniocerebral injury.