2Martin GS,Mannino DM,Eaton S,et al.The epidemiology of sepsis in the united states from 1979 through 2000[J].N Engl J Med,2003,348(16):1 546-1 554.
3Brun-Buisson C,Doyon F,Carlet J,et al.Incidence,risk factors,and outcomes of severe sepsis and septic shock in adults:a multicenter prospective study in intensive care unit french ICU Group for severe sepsis[J].JAMA,1995,274(12):968-974.
4Villar J,Maca-Meyer N,Perez-Mendez L,et al.Bench to bedside review:understanding genetic predisposition to sepsis[J].Crit Care,2004,8(3):180-189.
5Baughman RP,Lower EE,Flessa HC,et al.Thromobocytopenia in the intensive care unit[J].Chest,1993,104(4):1 243-1 247.
6Keh D,Boehnke T,Weber-Cartens S,et al.Immunologic and hemodynamic effects of low-dose hydrocortisone in septic shock:a double-blind,randomized,placebo-controlled,crossover study[J].Am J Respir Crit Care Med,2003,167(4):512-520.
7Shua F,Kobayashia H,Fukadowe K,et al.Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor dependent manner[J].FEBS Lett,2000,477(3):208-212.
8Bernard GR,Vincent JL,Laterre PF,et al.Efficacy and safety of recombinant human activated protein C for severe sepsis[J].N Engl J Med,2001,344(10):699-709.
9Joyce DE,Gellbert L,Ciaccia A,et al.Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis[J].J Biol Chem,2001,27(6):199-203.
10Jensen LE,Muzio M,Mantovani A,et al.IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein[J].J Immunol,2000,164(10):5 277-5 286.