Apoptin——一种特异性地促进肿瘤细胞凋亡的蛋白质

Apoptin:A Protein Which can Specifically Induce Apoptosis in Tumorigenic Cells

鸡贫血病毒 (CAV)的vp3基因编码的一种小蛋白质apoptin ,可以通过独立于 p5 3作用途径的、不被Bcl 2过量表达所抑制的方式 ,诱导肿瘤细胞或转化细胞凋亡 ,而对正常细胞不发挥作用 .Apoptin的这些特征使其可能成为一种有效的抗肿瘤药物 。

Chicken anemia virus vp3 gene encodes a small protein-Apoptin. It can induce apoptosis in tumorgenic or transformed cells but not in normal cells through a way that is independent of p53 reaction and can not be suppressed by the excessive expression of Bcl-2. All these facts make apoptin a potential antitumor agent. The unique way of apoptin inducing apoptosis is also useful to the study of the mechanisms of cell transformation and pathways of apoptosis.