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Alzheimer病的实验动物模型 被引量：5

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摘要 总结阿尔茨海默病(Ａｌｚｈｅｉｍｅｒ Ｄｉｓｅａｓｅ,ＡＤ)的动物模型近几年的研究成果,从神经纤维缠结、β淀粉样蛋白、脑组织损伤模型和转基因动物等几个方面讨论并比较这些动物模型在复制ＡＤ病理和行为改变方面的优点和不足,探讨如何制作出更理想的动物模型。
作者 张艳莉 张苏明 张旻
机构地区 华中科技大学同济医学院临床神经医学研究中心附属同济医院神经内科
出处 《中国临床神经科学》 2001年第4期421-423,共3页 Chinese Journal of Clinical Neurosciences
关键词 ALZHEIMER病 动物模型 神经纤维缠结 淀粉样蛋白 转基因
分类号 R749.16 [医药卫生—神经病学与精神病学] R-332 [医药卫生]
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参考文献20

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同被引文献20

  • 1BlaSS JP. Brain metabolism and brain disease: is metabolic deficience the proximale cause of Alzheimer dementia? J Neurosci Res, 2001,66(8):851-856.
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  • 5Dunnett SB, Everitt B J, Robins TW. The basal forebrain -cortical cholinergic system: Interpreting the function consequences of excitoxic lesions[ J]. Trends in Neuroscience, 1991,14( 11 ) :494 - 501.
  • 6Muir JL, Page KL, Sirinathsinghji DL, et al. Excitotoxic lesions of basal forebrain cholinergic neurons effects on learning memory and attention [ J ]. Behav Brain Res, 1993,57 (2) : 123 - 31.
  • 7CoyleJT, PriceDI, DelongMR. Alzheimersdisease: adisorderofcorticalcholinergicinnervation [ J ]. Science, 1983 ;219 ( 4589 ) : 1184.
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  • 9Gonzalez-Vidal MD,Cevera GM,Ruelas R,et al.Prosesterone:protective efects on the cat hippocampal neuronal damage due to acute global cerebral ischemia[J].Arch Med Res,1998,29(2):117-124.
  • 10Muir JL.Acetycholine,aging,and Alzheimer disease[J].Pharmacol Biochem Behav,1997,56(4):687-696.

引证文献5

二级引证文献13

中国临床神经科学
2001年 第4期

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