原发性高血压患者的纤维蛋白溶解活性变化

Changes of fibrinolytic activity in patients with essential hypertension

目的 观察未经治疗的原发性高血压患者的纤维蛋白溶解活性的变化及临床意义。方法 用发色底物法测定 42例原发性高血压患者和 40例血压正常者的血浆组织型纤维蛋白溶酶原激活物 (t PA)及其抑制剂 (PAI 1)的活性和纤维蛋白溶酶原 (Plg)活性。结果 原发性高血压患者血浆t PA活性明显低于血压正常者 ,PAI 1和Plg活性明显高于血压正常者。

Objective To investigate fibrinolytic activity and clinical significance in patients with essential hypertension.Methods The activities of tissue type plasminogen activitor(t PA),plasminogen activitor inhibitor 1(PAI 1),plasminogen(Plg) were measured by remant showing color assay in the serums of 42 patients with essential hypertension and normal persons.Results The hypertensive patients had significant higher activity of PAI 1 and Plg, whereas t PA activity was significantly lower.Conclusion These findings indicate that there is a endogenic fibrinolytic deficiency in essential hypertension.