非小细胞肺癌治疗反应状态的Cox分析

Assessment of response status in advanced NSCLC by Cox analysis

目的 评价非小细胞肺癌治疗反应状态的预后价值。方法 多因素风险模型分析了 116例晚期非小细胞肺癌患者不同治疗方法及其反应状态与生存期的相关性。结果 多因素分析结果显示 ,化疗、中药、缓解状态、体重变化是生存期相关风险因子 ;单因素分析结果显示 ,治疗后达到缓解和稳定的患者生存期无差异 ,而两者生存期明显长于进展者 ,体重增加和稳定者长于体重下降者。结论 评价晚期非小细胞肺癌预后不仅依赖治疗后的肿瘤缩小 ,而且肿瘤稳定、治疗后体重变化的指标也同样重要。

Objective To assess the value of treatment response in advanced non-small cell lung cancer(NSCLC). Methods The correlation of survival to various treatment responses in 116 cases of advanced NSCLC was analyzed by using Cox proportional hazard model. Results Multivariate analysis showed that chemotherapy, Chinese herbal medicine, response status of the tumor and loss of body weight were risk factors. Univariate analysis showed that there were no significant differences in survival between the cases with the tumors showing response to treatment or remaining stable, but the survival here was significantly longer than in the progressive cases. The survival was significantly longer in the patients putting on body weight than in those losing weight. Conclusion The prognosis of advanced NSCLC depends not only on the reduction of tumor size, but also on its stableness and the gaining of body weight.