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肾环磷酸腺苷含量下降与实验性肾病大鼠水潴留有关 被引量:2

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摘要 目的 确定血管升压素 (DDAVP)及其信使环磷酸腺苷 (cAMP)在实验性肾病大鼠水潴留中的作用。方法 将 42只大鼠分为两大组共 6个小组 ,每组 7只。第一大组为对照组 ,包括正常对照组 (组 1)、DDAVP组 (组2 )、DDAVP拮抗剂组 (组 3)。第二大组为肾病组 ,包括阿霉素 (ADR)组 (组 4)、ADR +DDAVP组 (组 5 )、ADR +DDAVP拮抗剂组 (组 6 )。测定肾髓质的cAMP含量、尿渗透压和血渗透压等的改变。结果 在给予DDAVP或DDAVP拮抗剂以后 ,第 1~ 6组大鼠的尿渗透压分别为 (1771.5± 879.4)、(2 145 .0± 936 .2 )、(176 3.6± 497.5 )、(10 49.6± 2 72 .3)、(1144 .8± 2 42 .8)和 (992 .7± 195 .7)mmol/L ,ADR肾病大鼠尿渗透压显著下降 ,其一级处理因素ADR的F值 (下同 )为 113.0 6 9,P =0 .0 0 0 44 3;血渗透压分别为 (30 2 .2± 8.7)、(2 96 .4± 9.5 )、(30 7.9± 6 .4)、(2 86 .2± 5 .3)、(2 88.5± 6 .2 )和 (2 90 .2± 6 .5 )mmol/L (F =17.30 2 2 ,P =0 .0 142 ) ;无溶质水清除率 (CH2O)分别为 (- 0 .84± 0 .44 )、(- 1.37± 0 .74)、(- 1.0 6± 0 .5 8)、(- 1.0 3± 0 .38)、(- 1.0 2± 0 .6 )和 (- 0 .85± 0 .49)ml/h (F =0 .0 2 41,P=0 .8843)。肾髓质的cAMP含量分别为 (6 5 2 .2 2± 15 1.97)。
出处 《徐州医学院学报》 CAS 2001年第6期461-463,共3页 Acta Academiae Medicinae Xuzhou
基金 江苏省教委自然科学基金资助项目 (94114)
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