摘要
目的 探讨微电极引导立体定向治疗帕金森病的疗效。方法 对60例帕金森病患者分别行苍白球腹后侧部(PVP)毁损术和/或丘脑腹中间核(Vim核)毁损术,观察术前及术后一周病人临床症状的改变情况。结果 术前和术后一周分别对病人行UPDRS评分,术前“开”状态评分为(47.82±6.48)分,术后一周评分为(22.73±4.64)分,得分下降了52.47％;术前“关”状态评分为(90.75±17.52)分,术后一周评分为(36.41±12.26)分,得分下降了59.88％。两种状态术前、术后评分均有显著性差异(P<0.01)。结论 微电极引导立体定向手术治疗帕金森病是一种疗效确切、并发症少、安全可靠的治疗方法。
Objective To assess the therapeutic effects of microelectrode-guided pallidotomy and/or thalamotomy on parkinson's disease (PD). Methods The microelectrode-guided pallidotomy or thalamotomy was carried out according to the patients' concrete conditions in 60 cases with PD. The clinical manifestations one week after the operation were analyzed and compared with preoperative those. Results The mean UPDRS scores in pre- and post-operative 'on' state were 47.82±6.48 and 22.73±4.64 respectively, while in the 'off' state, the UPDRS scores were 90.75±17.52 and 36.41±12.26 respectively. The difference between the pre- and post-operative UPDRS scores was significant (P<0.01) in these patients. Conclusion Microelectrode-guided stereotactic pallidotomy and/or thalamotomy is a quite effective, safe, and reliable therapeutic option for patients with PD.
出处
《中国临床神经外科杂志》
2001年第3期137-139,共3页
Chinese Journal of Clinical Neurosurgery
