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恶性脑胶质瘤基因治疗的临床研究进展 被引量：3

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摘要 恶性脑胶质瘤(MG)由于其发病机理和生物学行为的复杂性,单凭提高手术技巧和改进现有的传统治疗措施,要想获得彻底治愈是不可能的,这已被一个世纪以来的神经外科实践所证实.随着对神经肿瘤分子机理认识的不断深化和基因工程技术的发展,近十年来MG基因治疗已由基础研究的探索,迅速过渡到了临床试验性治疗.
作者 杨学军 浦佩王 等
机构地区 天津医科大学总医院神经外科
出处 《中国临床神经外科杂志》 2001年第3期188-190,共3页 Chinese Journal of Clinical Neurosurgery
关键词 胶质瘤 基因治疗 试验研究 MG 脑肿瘤
分类号 R730.264 [医药卫生—肿瘤] R739.41 [医药卫生—肿瘤]
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参考文献17

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同被引文献33

  • 1浦佩玉 杨学军.神经外科领域基础研究进展[J].中华神经外科杂志,2000,16:58-62.
  • 2杨学军 卫生部继续医学教育委员会.恶性胶质瘤的分子外科.国家继续医学教育项目教材神经外科学分册（第1版）[M].长春:长春出版社,1999.40-58.
  • 3[4]Benedetti S, Pirola B, Pollo B, et al. Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med, 2000, 6:447450.
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  • 5[7]Samoto K, Ehtesham M, Perng GC, et al. A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice. Neurosurgery, 2002, 50:599-605.
  • 6[8]Nanda D, Vogels R, Havenga M, et al. Treatment of malignantgliomas with a replicating adenoviral vector expressing herpes sim plex virus-thymidine kinase. Cancer Res, 2001, 61:8743-8750.
  • 7[9]Zhang Y, Jeong Lee H, Boado RJ, et al. Receptor-mediated delivery of an antisense gene to human brain cancer cells. J Gene Med, 2002, 4:183-194.
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  • 10[12]Sanson M, Marcaud V, Robin E, et al. Connexin 43-mediated bystander effect in two rat glioma cell models. Cancer Gene Ther, 2002, 9:149-155.

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中国临床神经外科杂志
2001年 第3期

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