肾康对嘌呤霉素肾病大鼠血液流变学的影响

Effects of ShenKang on blood rheology of rats with Nephrotic syndrome

目的 :探讨肾康口服液对嘌呤霉素肾病大鼠血液流变学的影响 :方法 :采用嘌呤霉素致大鼠肾病模型。治疗组灌服肾康口服液 ,正常组和模型组灌服生理盐水 ,对照组灌服雷公藤多甙混悬液。检测各组 2 4h尿蛋白定量、全血比粘度、血浆比粘度、血浆胆固醇及白蛋白水平。结果 :嘌呤霉素致大鼠肾病模型呈高粘血症 ,肾康组全血比粘度、血浆比粘度、血浆胆固醇及 2 4h尿蛋白定量下降 ,白蛋白水平升高 ,明显优于模型组。结论 :肾康口服液是通过升高血浆白蛋白、降低血浆胆固醇。

Objective: To investigate the mechanism of ShenKang in improving blood rheology in rats with nephrotic syndrome. Methods: A rat model of NS with Aminonucleoside Puromycin was used in this study. Rats were divided into three groups: group 1 was treated with ShenKang, group 2 treated with LeiGongTengDuoDai(LGTDD), and group 3 treated with water. In addition, normal rats were used as control. Whole blood ration viscosity, hemotoplasma ration viscosity, Cholesterol(TCH) and albuminuria(Alb) were measured in all groups. Results: Whole blood ration viscosity, hemotoplasma ration viscosity and TCH of ShenKang treatment group was significantly lower than NS group. It was superior to LGTDD group. Conclusion: The protecting effects of ShenKang on NS rats were mediated by decreasing levels of whole blood ration viscosity, hemotoplasma ration viscosity and TCH.