摘要
目的 :研究新型可吸收创面止血封固剂对大鼠肝脏切除创面的止血功效。方法 :采用大鼠肝脏切除术 ,与国外三种创面止血封固剂进行对比试验。结果 :( 1)新型可吸收创面止血封固剂具有与国外Tachocomb、Gelfix、Surgicel相近的止血速度 ,在体内 2 4~ 96小时可完全降解吸收 ,而且术后各项生化指标、病理检查均无显著性差异。 ( 2 )良好的亲水性能使其具有较强的粘附力。 ( 3 )不含蛋白质对人类各型血液的红细胞不发生凝集反应。 ( 4 )具有防止术后粘连的功效。结论 :经细胞毒性、遗传毒性、急毒、植入试验等均达到ISO标准 ,而且新型可吸收创面止血封固剂的价格仅为Tachocomb的 5 % ,可在临床手术中广泛应用。
Objective:A novel type absorbable wound hemostatic sealant on rat hepatectomic wound to study the hemostaic effect was reported in this letter.Methods:This material was compared with three kinds wound hemostatic sealant from abroad after rat hepatectomy.Results:Firstly,the hemostatic time of the novel type absorbable wound hemostatic sealant was almost the same as Tachocomb?Gelfix and Surgicel from abroad.The material could be completely absorbed and degraded within 24~96 hours.Furthermore,there was not significant difference in both several biochemical index and pathology examination.Secondly,The material has stronger adherence for its perfect hydrophilism.Thirdly,it doesn't cause agglutinate reaction to variants of human red cell without contenting protein.At last,it has the function of preventing postoperative adherence.Conclusion:The ISO standard of all of the indexes could be reached consisting cytotoxicity?genetic toxicity?acute toxicity and implantation tests et al.Moreover,the price of this absorbable wound hemostatic sealant is only 5% of Tachocomb,so it could be widely used in clinical operation.
出处
《武警医学院学报》
CAS
2001年第4期291-293,共3页
Acta Academiae Medicinae CPAPF