小剂量肝素对急性胰腺炎大鼠血流变学影响及胰腺病损程度的相关研究

The Effect of Small Dosage Heparin on the Hemorheology and Pathological Damage of Pancreas in Rats with Acute Pancreatitis

为了探讨小剂量肝素 (Heparin)对急性胰腺炎 (AP)大鼠血流变学的影响及与胰腺、胰外器官病理损害程度的关系 ,作者将 30只 Wistar大鼠随机分为假手术组、急性胰腺炎组和小剂量肝素治疗组 .实验 4 h后 ,观察各组血流变学、酶学、胰腺及胰外器官病损的改变 .观察发现 ,AP组血流变明显异常升高 ,和假手术组存在非常显著性差异 (p <0 .0 1) ,且胰腺及胰外器官病损明显 ;小剂量肝素治疗组上述变化明显减轻 ,和 AP组存在显著性差异 (p <0 .0 5 ) .结果显示 AP时大鼠存在血流变异常 ,且血流变异常程度和胰腺及胰外器官病损程度呈正相关 ,肝素能明显改善 AP大鼠的血流变异常 ,对胰腺及胰外器官有保护作用 .

To study the effect of small dosage heparin on hemorheology and pathological damage of pancreas in rats with acute pancreatitis. 30 Wistar rats were divided into 3 groups; a control group, a group of acute pancreatitis(AP), and a group of acute pancreatitis with the treatment of heparin in small dosage. Hemorheology, enzyme, and the pathological alteration in pancreas and in other organs were observed 4 hour after experiments. Results indicated that hemorheology was significantly higher, and the pathological damage in pancreas and in other organs was obvious in AP, as compared with the control group (p<0.05). H was concluded that hemorheology was abnormal in rats with AP, and the abnormal hemorheology was positively correlated with the damage in pancreas and in other organs. Heparin can improve abnormal hemorheology in rats with AP and protect pancreas and other organs.