砷剂化合物作用机制的研究概况(综述)

General feature of arsenic therapeutic mechanism(A review)

砷剂对急性早幼粒细胞白血病有良好的疗效 ,研究发现砷剂的作用机制可能包括 :(1)诱导细胞凋亡和部分分化 ;(2 )调控细胞凋亡基因的表达 ;(3)使线粒体内膜跨膜电位(transmembranepotential,ΔΨm)下降 ;(4 )阻抑细胞增殖。

Arsenic has efficient cure effect on acute promyelocytic leukemia(APL). Studies showed that arsenic therapeutic mechanism could be 1) induced cell apoptosis and partial differentiation, 2) regulated apoptotic gene, 3) disrupted transmembrane potential(ΔΨm), 4) inhibit cell proliferation.