妊娠期纤溶状态的实验观察

FIBRINOLYTIC ACTIVITY MEASUREMENT IN PREGNANCY

应用纤溶活性比色定量分析法观察了132例早、中、晚期国人健康孕妇静脉血浆纤溶活性的变化。结果:孕期静脉血浆纤溶总活性呈持续性降低,纤溶抑制活性及纤溶酶原活性持续升高(P皆<0.01)。晚孕组纤溶激活活性显著降低(P<0.05)。证明孕期处于低纤溶状态。

Fibrinolytic activities were measured in 132 healthy pregnant and 30 nonpregnant women with a penal of self-comparable caseinolytic tests. Venous plasma total fibrinolytic activity in 132 haelthy women in pregnancy (-16.07±1.73 μmol tyrosine/ml)was significantly(P<0.01)decreased as compared with -12.69±1.35 in 30 non-pregnant controls.Healthy pregnant women had significant(P<0.01)increase in both plasma fibrinolytic inhi- bition activity(26.28±3.48;22.86±3.54 for non-pregnant controls)and plasma plasminogen activity(25.53±2.79;20.70±2.64 for non-pregnant controls).Whereas the plasma fibrinolytic activation activity was significantly(P<0.05)decreased only in the third trimester.There were an obveious positive correlation(γ=0.4613 P<0.01)between gestational age and plasma fibrinolytic inhibition activity and a significant inverse correla- tion between gestational age and plasma total fibrinolytic activity(γ= -0.1804 P<0.05).These results suggest that alternations both in plasma fibrinolytic activation activity and fibrinolytic inhibition activity contribute to the physiological hypofibrinolytic state in pregnancy.Physiological para- meters of fibrinolytic activities in Chinese women during pregnancy were preliminarily defined via this research,which might put foundamental insight into further research on mechanism,diagnosis,prevention and treatment of hemorrhagic and thrombo-embolic complications in pregnancy.