ATⅢ、Fg、FDP和尿酸测定在诊断妊娠高血压综合征中价值的比较

COMPARISON OF THE DIAGNOSTIC VALUES OF ANTITHROMBIN Ⅲ,FIBRINOGEN,FDP AND URIC ACID DETERMINATIONS IN GESTATIONAL HYPERTENSION SYNDROME

研究了225例正常晚孕者和妊娠高血压综合征(妊高征)患者的抗凝血酶Ⅲ(ATⅢ)活性、纤维蛋白原(Fg)、纤维蛋白降解产物(FDP)和尿酸的改变。结果表明,ATⅢ具有最高的判别效率,在多数妊高征患者中,ATⅢ活性低于对照组一个标准差,选择ATⅢ活性低于80%为本病的预测值,ATⅢ预测本病的敏感性和特异性分别为71%和82%。与尿酸测定比较,ATⅢ活性预测准确性较高,可成为诊断本病一项有实用价值的指标,

Four parameters:antithrombin Ⅲ(AT Ⅲ)activity,fibrinogen, fibrin degradation produets(FDP)and uric acid were measured in 225 pregnant women and patients with gestational hypertension syndrome(GHS) and their values in the diagnosis of GHS were analysed.It has been found,based on the Bayes discriminant analysis,that AT Ⅲ activity has the highest discriminating efficiency among the four variables investi- gated.AT Ⅲ activity in most of the GBS patients lower than(?)-1 s of the value of controls.An AT Ⅲ activity less than 80% was selected as indicative of GHS.The sensitivity and specificity of AT Ⅲ activity for GHS were 71% and 82% respectively.Importantly,an AT Ⅲ activity higher than 80% predicted the absence of GHS in 83% of the investigated patients.Compared with the determination of uric acid,AT Ⅲ activity had a more accurate predictive value.These findings suggest that AT Ⅲ activty measurement might be a potentially useful laboratory parameter in the diagnosis of GHS