不同剂量醋酸甲羟孕酮用于哺乳期妇女避孕的临床研究

A clinical study on contraception of breast-feeding women with different dosage of DMPA.

目的 探讨不同剂量醋酸甲羟孕酮 (DMPA)用于哺乳期妇女避孕对其避孕效果、副反应发生率及停用原因的影响。方法 将受试对象按剂量随机分为 12 0mg和 15 0mg两组 ,排除不符合研究标准者 ,纳入研究对象共计 173例 ,12 0mg组 87例 ,15 0mg组 86例。每 3个月深部肌肉注射 1次 ,共 4次。 结果 两组避孕成功率均为 10 0 0 0 % ;发生副反应中 ,点滴出血 12 0mg组为 6 90 % ,明显低于 15 0mg组的 16 2 8% (P <0 0 5 )。结论 12 0mgDMPA用于哺乳期妇女避孕不影响其有效性 ,且可减少副反应发生率。

Objective To discuss the effects of contraception by different dosage of DMPA on the breast feeding women,as well as the side effects and the cause of having to stop the medicine.Methods 173 subjects were injected randomly with 120mg and 150mg DMPA(87 with 120mg and 86 with 150mg).They were deeply injected 4 times,once every 3 months.Results Both of the two groups showed 100\^00% successful rate.A bit bleeding counted for 6\^90% in 120mg group,clearly lower than that in 150mg group(16\^28%)(P<0\^05).Conclusion 120mg DMPA could applied to the contraception of breast feeding women with little side effects.