大白鼠感染广州管圆线虫后各脏器的病理变化观察

Pathologic observation on the rats infected by angiostrongylus cantonensis

目的 :观察动物感染广州管圆线虫 (AC)后各脏器的病理变化。方法 :用光镜及电镜观察大白鼠受感染后心、肺、脑、肝、肾及脾等脏器的形态改变。结果 :主要的靶器官是脑、心、肺。出现虫体栓塞、虫卵结节形成 ,实质细胞损伤坏变 ,伴随炎症反应与继发感染等。脾、肾、肝无明显病理变化。结论 :广州管圆线虫对大白鼠的损伤主要是由虫子的移行和产卵发育刺激而致 ,其可引起肺心脑的栓塞和肉芽肿性虫卵结节及炎症。严重的肺动脉栓塞、广泛的虫卵结节及继发肺感染是主要的致死原因。

Objective:To study the pathological changes of rats with angiostrongylus cantonensis(AC).Methods:The morphological damages in heart,lungs, brain,liver,kidney and spleen of rats infected by A. Cantonensis with light and electron microscope.Results:The target organs are the brain,heart and lungs Thrombus,worm eggs node the matter cell degeneration with inflammation and secondary infection et al were observed. The liver,kidney and spleen showed no significant pathological changes.Conclusion:The major pathological injury in the rats with A. Cantonensis is the division of worm and the stimulation of worm egg development.Which lead to the inflammation of the lungs,heart and brain. Serious pulmovascular adult worm blocking,diffuse egg nodes and concomitant lung abscess and infection is the major death-causing factor.