消化系肿瘤T细胞亚群NK B细胞表面抗原检测的意义

Detection and significance of T cell subpopulations in digestive system tumor

目的 了解消化系统肿瘤患者的免疫状态 ,探讨T细胞亚群、NK细胞、B细胞表面抗原与消化系统肿瘤的关系。方法采用流式细胞仪分别检测34例消化系统肿瘤患者外周血T细胞亚群 :CD3+、CD4+、CD8+,以及CD19+、CD16+CD56+的淋巴细胞百分数 ,其中食道癌10例 ,胃癌8例 ,肝癌6例 ,大肠癌10例 ,并与20例正常对照比较。结果 消化系统肿瘤患者CD3+、CD4+、CD16+CD56+均较正常对照组低 (P<0.05),CD8+高于对照组(P<0.05) ,CD19+与正常对照无显著差异(P>0.05),各免疫指标在消化系统肿瘤之间无显著差异(P>0.05)。结论 消化系统肿瘤患者细胞免疫功能普遍低下 ,T细胞亚群、NK细胞。

Objective To understand the immune status of the patients with digestive system tumor, and to discuss the relationship between T cell subpopulations and the development of tumor. Methods T cell subpopulations including CD3+, CD4+, CD8+, CD19+, CD16+, CD56+ were detected with flow cytometry in 34 patients 10 esophageal cancer, 8 gastric carcinoma, 6 hepatocarcinoma,10 large intestine cancer) and 20 normal controls. Results CD3+, CD4+, CD16+ and CD56+ of digestive system tumor patients were all lower than control group (P<0.05), while CD8+ was higher than control group (P<0.05), CD19+ had no significant difference with control group (P>0.05). There were no significant differences among different kinds of digestive system tumor patients (P>0.05). Conclusion The cellular immunity of digestive system tumor patients were commonly low, which may have some action on the occurrence and development of tumor.