胃癌组织中P16蛋白的表达及其与预后的关系

The expression of P16 protein and correlation with prognosis of gastric carcinoma.

目的 :了解P16蛋白在胃癌发生、发展中的作用及其与预后的关系。方法 :应用免疫组化方法对 6 0例胃癌、18例胃良性疾病及 15例胃正常组织中P16蛋白的表达情况进行检测。结果 :胃癌组织中P16蛋白的阳性率 (2 5 % )低于胃良性疾病 (6 1 11% )及胃正常组织 (6 3 33% ) ,差异有显著性 (P <0 0 5 )。P16蛋白的表达与胃癌的组织分化、临床分期、淋巴转移及预后关系密切 (P <0 0 5 ) ,与患者年龄、性别、肿瘤位置无关。结论 :P16基因蛋白在胃癌的发生、发展过程中起了重要作用。P16蛋白可作为判别胃良。

Objectives:To study the expression of P16 protein in gastric carcinoma and research the effect and relation with prognosis.Methods:The expression of P16 protein was determined in 60 cases of gastric carcinoma,18 case of benign gastric diseases and 15 cases of normal gastric tissue with immunohistochemical method.Results:The positive rate of P16 protein in gastric carcinoma was lower than that in benign gastric diseases and in normal gastric tissue ( P< 0 05).The expression of P16 was closely correlated to tumor histodifferentiation type,degree of differentiation,lymph node metastasis and prognosis of patients with gastric carcinoma.Conclusions:The results suggest that P16 protein may play an important rote in the occurrence and development of the gastric carcinoma.The expression of P16 protein might be a indicator for assessing benign and malignant disease and prognosis of patient with gastric carcinoma.