人参皂苷Rg_2与毒毛旋花子苷K的强心作用及毒性比较

Comparison of cardiotonic and toxic effects between ginsenoside Rg_2 and strophanthin K

目的 观察人参皂苷 Rg2 (简称 Rg2 )与毒毛旋花子苷 K(SK)对衰竭犬心的强心作用及毒性比较。方法 复制戊巴比妥钠致心力衰竭模型。给予 Rg2 0 .5 mg/m in和 SK0 .0 6 2 5 mg/m in,观察对心功能的影响及药物毒性反应。结果 二药均能升高血压 (BP)、加强心肌收缩力 ,增加左室内压 (L VSP)和左室内压最大变化速率 (± dp /dtmax) ,强心效力 SK稍大于 Rg2 ,但治疗宽度及治疗指数 Rg2 明显大于 SK。结论 Rg2 是一种安全范围宽的中效强心药物。

Object To observe and compare the cardiotonic and toxic effects of ginsenoside Rg 2 (Rg 2) and strophanthin K (SK) Methods In duplicated heart failure model induced by sodium pentobarbital either Rg 2 0 5 mg/min or SK 0 062 5 mg/min were given by iv to observe the cardiotonic and toxic effects on the models Results Both of them can improve blood pressure, strengthen myocardium contractility and increase LVSP and ±dp/dt max SK has a stronger maximum cardiotonic effect, while Rg 2 has a broader therapeutic margin and higher therapeutic index Conclusion Rg 2 is a cardiotonic of medium effect with broader therapeutic margin