青霉素G钾盐在CTAB胶束中的水解及其抑制

Inhibition of the Hydrolysis of Pen-K in CTAB Micelle Systems

以紫外光谱法研究了青霉素G钾盐(Pen-K)在十六烷基三甲基溴化铵(CTAB)胶束体系中的水解反应,并探讨了水解反应机理.结果表明,CTAB胶束对Pen-K的水解具有抑制作用;Pen-K在CTAB胶束体系水解时,体系pH值的变化与在水中相似,表明H+浓度对这种抑制作用影响较小.红外光谱和微极性研究表明,部分Pen-K钾盐定位于CTAB胶束栅栏层中,增加了其稳定性.

The hydrolysis reactions of Pen-K in water and in CTAB micelles have been studied by UV. spectra. The results show that CTAB micelles can inhibit the hydrolysis, but tale tendency of pH value change of the hydrolysis of Pen-K in the CTAB micelles is the sane as that in water, which indicates that H+ concentration has small effect on the inhibition. The investigations of IR and micro-polarity show that the stability of Pen-K is increased by the location of some Pen-K in the railings of the CTAB micelles.