纳洛酮治疗急性重型脑梗死的疗效观察

Therapeutic Effects of Naloxone in the Treatment of Acute Serious Cerebral Infarction

目的探讨纳洛酮针剂对急性重型脑梗死的临床疗效。方法将 96例患者按入院顺序随机分为治疗 A组 30例 ,治疗 B组 2 8例 ,对照 C组 38例 ;C组仅给予基础治疗 ,A、B2组分别在 C组基础上予纳洛酮 1.6 mg、 3.2 m g静脉滴注 ,每日 1次 ,共 10 d 1疗程 ,治疗前后进行神经功能缺损评分和疗效评定 ;并比较治疗 2 4 h、 3d各组的转醒率、 1周内肌力的变化及不良反应等。结果 A组显效率 6 0 .0 % ,有效率 86 .7% ,B组分别为 75 .0 %、 96 .4 % ,C组 2 8.9%、 6 8.4 % ;A组用药 2 4 h、 3d转醒率分别为 36 .7%、 90 .0 % ,B组为 6 7.9%、 10 0 % ,C组 18.4 %、 71.1% ;各组治疗 1周肌力增加 级的比例分别为 A组 4 8.5 %、 B组 5 6 .4 %及 C组 39.2 %。结论纳洛酮针剂有利于急性重症脑梗死患者神经功能的恢复 ,大剂量疗效更好 ,并有明显促醒作用 。

Objective To investigate the clinical therapeutic effects of naloxone injection in the treatment of acute serious cerebral infarction. Methods Ninety-six cases of acute serious cerebral infarction were randomly divided into treatment group A ( n =30), treatment group B ( n =28) and control C group ( n =38). Group C received basic treatment, groups A and B received intravenous drop of naloxone 1.6 mg and 3.2 mg respectively, once every day, beside basic treatment. One course consisted of 10 days. Consciousness, myodynamic recovery and side effect were observed. Nerval function defect grade and therapeutic effect evaluation were performed before and after treatment. The conscious recovery rate and changes in myodynamia within one week were compared among the three groups 24 h and 3 days after treatment. Results The excellent rate and effective rate were 60.0 % and 86.7 %, 75.0 % and 96.4 %, and 28.9 % and 68.4 % respectively in the groups A, B and C. The ratio of the increased grade I of myodynamia was 48.5 %, 56.4 % and 39.2 % respectively in the groups A, B and C after treatment for one week. Conclusion Naloxone injection was beneficial to the recovery of nerval function of the patients with acute serious cerebral infarction. High dose of naloxone had better therapeutic effect.