卵巢癌中谷胱甘肽S-转移酶-π的表达与化疗反应的关系

Relationship Between the Expression of Glutathione S-Transferase-π and the Response to Chemotherapy in Ovarian Cancer

目的 :了解卵巢癌中谷胱甘肽S 转移酶 π(GST π)的表达与化疗的关系。方法 :运用免疫组织化学技术对 74例术前未治疗的上皮性卵巢癌进行GST π检测。结果 :74例卵巢癌中GST π阳性 5 5例 ,阳性率为 74.3%。卵巢癌中GST π的表达与病理类型无相关性 (P >0 .0 5 )。对首次术后有残余癌的 2 7例患者行化疗反应评价 ,GST π阳性者与阴性者的化疗反应率为 13.3%及 83.3 % ,两者间差异有显著性 (P <0 .0 1)。GST π阳性对耐药的预测值为 86 .7% ,GST π阴性对化疗反应的预测值为 83.3%。结论 :未治疗卵巢癌中存在着由GST π介导的内在性耐药机制 ,GST π的表达能较好地预测化疗反应。

Objective:To determine the relationship between the expression of glutathione S transferase π (GST π) and the response to chemotherapy in ovarian cancer.Methods:Expression of GST π was immunohistochemically studied in paraffin sections from 74 patients with ovarian cancer who had not received any chemotherapy before surgery.Results:GST π immunoreactivity was present in 55 (74.3%) of the tumor tissues and was not associated with histopathologic types.Of 27 clinically measurable lesions after surgery,the response rate to chemotherapy in GST π positive group (13.3,2/15) was significantly lower than that in the GST π negative group (83.3,10/12;P<0.01).The predictive value of positive GST π staining for drug resistance was 86.7%,and that of negative staining for objective responders was 83.3%.Conclusion:The data suggest that GST π expression in tumor cells is related to drug resistance of the patients with epithelial ovarian cancer and is a useful marker of response to chemotherapy.