检测血清层粘连蛋白、Ⅳ型胶原对糖尿病早期肾损害的意义

Clincal significance of detecting laminin and type Ⅳ collagen in diabetic patients with early renal damage

目的 探讨糖尿病早期肾脏损害时血清层粘连蛋白、Ⅳ型胶原水平变化的意义。 方法 应用放射免疫法直接检测病人血清中层粘连蛋白、Ⅳ型胶原水平。 结果 糖尿病早期肾脏损害时血清层粘连蛋白、Ⅳ型胶原水平明显或成倍高于健康对照组（P＜0．01），敏感性明显高于血清中Urea、Cr和尿中蛋白。 结论 病人血清中层粘连蛋白、IV型胶原水平升高可作为较早反映糖尿病肾损害的报警指标，也可作为糖尿病肾病的早期诊断有用的指标。

 Objetive To investigate the clinical significance of serum laminin (LN) and type IV collagen(IV－C) concentration in early renal damage in diabetic patients． Method Serum LN and (IV－C) were detected with radioimmunoasay in 54 diabetic patients and 40 healthy controls． Results The mean concentrations of serum LN and IV－ C in 54 diabetic patients were significantly higher than those of healthy controls (P＜0．01)with their sensitivity notably higher than those of urea Cr and urinary protien． Conclusion Elevation of serum LN and IV－C levels in diabetic patients acts as an early alarm of renal damage and may be used as an index for early diabetic nephropathy． 