大肠埃希菌超广谱β-内酰胺酶的检测及药敏分析

Analysis on antibiotic－resistance of extend－spectrum beta lactamases producing Escherichia coli

目的 了解本地区大肠埃希菌产超广谱β－内酰胺酶（ESBLs ）的耐药情况。以利于对产ESBLs菌的监控和治疗。 方法 对本院分离出273株大肠埃希菌进行了ESBLs检测和对17种抗生素的耐药性测定。ESBLs检测采用VTIEK32全自动微生物分析仪，药敏试验采用K－B法。 结果 273 株大肠埃希菌中有53 株产ESBLs，检出率为19．41％。 结论 产ESBLs大肠埃希菌不容忽视，而对产ESBLs大肠埃希菌感染的治疗，亚胺培南应考虑作为首选的药物。

 Objective To investigate the drug－ resistance of strains extended sectrum β－lactmase (ESBLs) producing Escherichia coli in order to control such strains． Methods Two hundred and seventy three strains of ESBLs－producing E． coli were determined by VITEK－ 32 and antibiotic susceptiblity tests on 17 kinds of antibiotics by K－B test． Results Fifty three of 273(19．41％)isolates produced ESBLs． All the tested strains were susceptible to imipenem． Conclusion It is necessary to pay attention to the antibiotic resistance of ESBLs－producing E． coli． Imipenem is of first choice used in infections resulted from ESBLs－producing E．coli． 