无法切除的胰腺癌的综合治疗

Multimodality Treatment of Unoperable Carcinoma of the Pancreas

目的 :探讨晚期胰腺癌的合理治疗策略。方法 :从本院 1990年 1月～ 1997年 12月收治的 5 5例不能手术切除病例中 ,按不同治疗手段分为 :内引流组 (Ⅰ ) ,内引流加化疗组 (Ⅱ ) ,内引流加放化疗联合组 (Ⅲ ) ,进行分析比较。结果 :Ⅱ、Ⅲ组疼痛缓解明显优于Ⅰ组 ,Ⅰ、Ⅱ、Ⅲ组平均生存期 (月 )分别为 3 .97± 1.44 ,6 .85± 1.87,9.43±2 .84(P <0 .0 1)。结论 :放化疗联合更有效提高患者生活质量 ,延长患者生存时间。

Objective: To investigate the strategy for treatment of advanced carcinoma of the pancreas. Methods: From January 1990 to December 1997,55 cases with unresectable carcinoma of the pancreas were treated in our hospital. According to the treatment modality, the patients were divided into three groups: Group I by pass procedur, Group Ⅱ by pass procedure and chemotherapy, and Group Ⅲ by pass procedure, chemotherapy and radiotherapy. The relief rate of symptoms and survival time were observed. Results: The rates of pain relief were significantly high in Group Ⅱ and Group Ⅲ. The average survival time(months) was 3.97±1.44,6.85±1.87,and 9.13±2.84 in Group I, Group Ⅱ and Group Ⅲ respectively(P<0.01). Conclusion: Pass procedure combined with chemotherapy and radiotherapy can remarkably improve the quality of life and prolong the survival time for the advanced carcinoma of the pancreas.