6Souglakos J ,Mavroudis D,kakolyris S, et al. Triplet combination with irinotecan plus oxaliplatin plus continuous-infusion fluorouracial and leucovorin as first-line treatment in metastatic colorectal cancer: a multicenter phase Ⅱtrial[J]. J Clin Oncol,
7Raymond E, Faivre S, Woynarowski JM, et al. Oxaliplatin: mechanism of action and antineoplastic activity[J] . Semin Oncol,1998, 25(Suppl 5):4-12.
8Grand TG, Dattino RM, Efficacy E, et al.Circadian optimization of irinotecan and oxaliplatin in mice with glasgow osteosarcoma [J]. Br J Cancer, 2002, 86(6):999-1005.
9Yip D,Karapetis C,Strickland AH,et al.A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies[J].Ann Oncol,2003,14(6):864-866.
10De Gramont A,Figer A,Seymonr M,et al.Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer[J].J Clin Oncol,2000,18(16):2938-2947.
