IL-6基因在髓母细胞瘤中的表达

The examination of inteleukin-6 gene by ISH in human medulloblastomas

目的 :研究髓母细胞瘤中IL - 6基因表达与肿瘤发生和发展关系。方法 :用地高辛标记IL - 6cDNA探针原位杂交法检测IL - 6mRNA在 16例髓母细胞瘤和 10例正常脑组织中的表达。结果 :髓母细胞瘤表达率明显高于对照组 ,差异非常显著 (P<0 .0 1)。表明IL - 6mRNA表达与组织类型有关。结论 :IL -

Objective:To investigate the significance of IL-6 gene expression in medulloblastomas and its relationship with the evolution and progression in medulloblastoma.Methods:Digoxin-labelled IL-6 cDNA probe was used to detect the expression of IL-6 mRNA by in situ hybridization in 16 cases of medulloblastomas and 10 cases of normal brain tissues.Results:The expression rate in medulloblastomas was much higher than that in normal brain tissues ( P <0.01).The expression of IL-6 mRNA was associated with the type of the tissue.Conclusion:IL-6 may be one of the important factors in oncogenesis and development of medulloblastoma.