中成药保济丸挥发性化学成分的研究

Studies on volatile constituents in Chinese medicinal preparation "Pao Chai Pill

目的 为了改变中成药羊城“保济丸”的剂型 ,我们对羊城“保济丸”和香港“保济丸”的挥发性化学成分进行比较研究。方法 应用超声波提取技术分别提取中成药羊城“保济丸”和香港“保济丸”的化学组分 ,采用气相色谱 -质谱联用法鉴定化学成分。通过标准图谱对照确定化合物。峰面积归一化法计算相对百分含量。结果 鉴定出羊城“保济丸”2 4种化合物 ,香港“保济丸”2 0种化合物。结论 羊城“保济丸”倍半萜内酯相对百分含量多于香港“保济丸”,而倍半萜醇类、倍半萜类相对百分含量少于香港“保济丸”。

Object To study the volatile constituents in the TCM preparation 'Pao Chai Pill' made in Yangcheng (Guangzhou) (YPCP) in comparison with that made in Hongkong (HPCP) to gain some insight for the renewal of YPCP to a new dosage form Methods The volatile constituents were extracted with the aid of ultrasonic wave in organic solvent, and identified by GC-MS and elucidated on the standard MS data Their relative contents in percentage were calculated by area normalization Results 24 and 20 volatile constituents were identified in YPCP and HPCP respectively Conclusion YPCP showed more rich in sesquiterpene lactones but less sesquiterpenes and sesquiterpene alcohols than HPCP