红花化学成分的研究

Studies on chemical constituents of Carthamus tinctorius

目的 为进一步揭示红花 Carthamus tinctorius L .药理活性的化学物质基础 ,开发其活性成分 ,我们对其进行了较为深入系统的化学成分研究。方法 经大孔树脂、硅胶和 Sephadex L H- 2 0反复柱层析分得并通过波谱分析鉴定了 12个化合物。结果 它们分别为 :2 ,3,4,9- tetrahydro- 1- m ethy1- 1- H- pyrido [3,4- b]indole- 3- carboxylicacid( ) ;thymine- 2 - desoxyribofuranoside( ) ;ethyl- α- D- lyxofuranoside( ) ;kaem pferol- 3- O- rutinoside( ) ;sy-ringin ( ) ;quercetin- 3- O-β- D - galactoside( ) ;safflor yellow - A ( ) ;carthamin( )和阿魏酸、对羟基桂皮酸、胡萝卜苷、β-谷甾醇。结论 化合物 、 和 为首次从该植物中分得。化合物 对 ADP诱导的大鼠血小板聚集有较好的抑制活性。

Object To carry out a continual systematic study on the chemical constituents of Carthamus tinctorius L in order to reveal the pharmacological active components for their further deve lopment Methods By repeated chromatographic separation on macroporus resin, silica gel, Sephadex LH 20 and spectral analysis Results: Twelve compounds were obtained and identified as 2,3,4,9 tetrahydro 1 methyl 1 H pyrido [3,4 b] indole 3 carboxylic acid (Ⅰ); thymine 2 desoxyribofuranoside (Ⅱ); ethyl α D lyxofuranoside (Ⅲ); kaempferol 3 O rutinoside (Ⅳ); syringin (Ⅴ); quercetin 3 O β D galactoside (Ⅵ); safflor yellow A (Ⅶ); carthamin (Ⅷ) and ferulic acid, p hydroxycinnamic acid, daucosterol, β sitosterol Conclusion Compounds Ⅰ,Ⅱ and Ⅲ were obtained from this plant for the first time Compound Ⅶ showed antiplatlet aggregation activity induced by ADP in rats