1[1]Ito Y, Miyoshi E, Takeda T, et al. Expression and possible role of ets-1 in hepatocellular carcinoma[J]. Am J Clin Pathol,2000,114(5):719
2[2]Brembeck FH, Opitz OG, Libermann TA, et al. Dual function of the epithelial specific ets transcription factor, ELF3, in modu lating differentiation[J]. Oncogene,2000,19(14): 1764
3[3]Tymms MJ, Ng AY, Thomas RS, et al. A novel epithelial-ex presed ETS gene, ELF3, human and murine cDNA sequences,murine genomic organization, human mapping to 1q32.2 and ex pression in tissues and cancer[J]. Oncogene, 1997,15 (20) :2449
4[4]Zhou J, NG AY, Tymms MJ, et al. A novel transcription fac tor, ELF5, belongs to the ELF subfamily of ETS genes and aps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines [J]. Oncogene,1998,17(21) :2719
5[5]Edel MJ. Analysis of the TEL protein during tumor angiogenesis[J]. Anticancer Res, 1999,19(4B):2945
6[6]Jukka W, Arun S, Veli-Matti K. Differenrial regulation of in terstitial collagenase (MMP-1) gene expression by ETS tran scription factors[J]. Oncogene, 1997,14: 2651
7[7]Nishioka Y, Kobayashi K, Sagae S, et al. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter in endometrial carcinomas[J]. Jpn J Cancer Res, 2000,91 (6):612
8[8]Ozaki I, Mizuta T, Zhao G, et al. Involvement of the Ets-I gene in overexpression of matrilysin in human hepatocellular car cinoma[J]. Cancer Res,2000,60(22) :6519
9[9]Hanzawa M, Shindoh M, Higashino F, et al. Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase gene[J]. Carcinogenesis, 2000,21 (6): 1079
10[10]Tsang KJ, Crowe DJ. Retinoic acid and extracellular matrix inhi bition of matrix metalloproteinase 9 expression is mediated by the mitogen activated protein kinase pathway[J]. Int J Oncol, 2001,18(2):369
4Zhang, S Y, Yi Y H, Tang, H F, et al. Bioaetive triterpene glycosides from the sea cucumber Holothuria fuscocinerea[J]. J Nat Prod, 2006, 69(10):1492.
5ttu X Q, Wang Y M, Wang J F, et al. Dietary saponins of sea cucumber alleviate orotie acid-induced fatty liver in rats via PPARa and SREBP-1 e signaling[J]. Lipids Health Dis, 2010, 9(1):25. 1.
6Fang T, Zhu C H, Zhang X W, et al. Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and avβ3 integrin via binding to the extracellular domain of KDR[J]. Mol Pharmacol, 2007, 72(3): 545.
7Eccles S A. Heparanase: breaking down barriers in tumors [J]. Nat Med, 1999, 5(7):735.
8Whitelock J M, Murdoch A D, Iozzo R V, et al. The degradation of human endothelial cell-derived perlecan and release of bound basic fibrohlast growth factor by stromelysin, collagenase, plasmin, and heparanases [J]. J Bio Chem, 1996, 271(17):10079.
9Zinzalla V, Hall MN. Signal transduetion: Linking nutrients to growth[J]. Nature, 2008, 454(7202):287.
10Thiantanawat A, Long BJ, Brodie AM. Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens[J]. Cancer Res, 2003, 63(22) :8037.
