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他汀类药物非降脂作用临床研究进展 被引量:2

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摘要 他汀类药物抗动脉粥样硬化、降低血小板活性、改善内皮功能、抑制平滑肌细胞增殖、减少心肌梗塞及中风等心血管并发症的发生率、抗增殖及抑制法尼基作用、免疫抑制作用、增强骨密度、抗老年痴呆等非降脂作用的发现,延伸、扩大了其临床适应症。对其深入研究,使人们了解该类药物的作用范围及相关疾病的病理进入新的层次。他汀类药物在治疗心血管疾病和非心血管病时安全有效、易耐受,并且蕴藏着极大的临床应用潜力。
出处 《中国药业》 CAS 2001年第12期1-3,共3页 China Pharmaceuticals
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  • 1羊镇宇,薄小萍,朱剑秋.氟伐他汀对高脂血症患者血小板CD62p的影响[J].临床心血管病杂志,2000,16(9):406-407. 被引量:5
  • 2Aviram M, Hussein O, Mira R. Interaction of platelets, macrophage and lipoproteins in hypercholesterolemia: Antiatherogenic effects of HMGCoA reductase inhibitor therapy [ J ]. J Cardiavasc Pharmacol, 1998,31:39 - 45.
  • 3Barrow N,Stratton PD,Benjiamin N. Reduction of LDL cholesterol by pravastatin does not influence platelet action in patient with mild hyercholesterolaemia at risk of coronary heart disease[J]. Br J ClinPharmacol, 1991,32:127 - 129.
  • 4Jarvisalo MJ,Toikka JO,Vasanfari J,et al. HMG - CoA reductase inhibitor are related to improved systemic endothelial fuction in coronary artery disease [ J ]. Athersclerosis, 1999,147 (2): 237 - 242.
  • 5Brandes RP,Behra A. Lovastatin maintains nitric oxide,but not EDHF mediated endothelium- dependent relaxation in the hypercholesterolemic rabbit carotid artery[J]. Atherosclorosis, 1999,147(1 ) :97 - 104.
  • 6Negre AP, Vanvliet AK. Inhibition of proliferation of human smooth cells by various HMG- CoA reductase inhibitors; comparison with other human cell types [J]. Biochim Biophys Acta Lipids Metabol,1997,1345(3) :259.
  • 7David J , Maron MD, Sergio F, et al. Current Perspective on Statins[J ], Circulation, 2000,101: 207 - 213.
  • 8Ganz DA, Kuntz KM, Jacobson GA,et al. Cost - effectiveness of 3 -hydroxy-3- methyl-glutaryl coenzyme A reductase inhibitor therapy in older patients with myocardial infraction[J]. Ann Intern Med,2000,132(10) :780 - 787.
  • 9Rosenson RS. Biological basis for statin therapy in stroke prevention[J]. Curr Opin Neurol,2000,13( 1 ) :57 - 62.
  • 10Wassman S, Nickenig G, Bohn M,et al. HMG- CoA reductase inhibitor atorvastatin downregulation AT1 receptor gene expressin and cell proliferation in vascular smooth musccle cells[J]. Kideney Blood Presses Res, 1998,21(5):392.

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