头风胶囊对偏头痛大鼠单胺类神经递质含量的影响

Toufeng Capsule's Influence on Concentration of Neurotransmitter and Blood Active Substance in Brain and Blood of Magraine Mice

目的 :研究头风胶囊对大鼠脑组织和血中单胺类神经递质含量的影响及其作用机制。方法 :皮下注射硝酸甘油注射剂 ,造成大鼠实验性偏头痛模型 ;给予头风胶囊治疗后 ,采用荧光分光光度法测定各实验组大鼠脑组织和血中 5 羟色胺、去甲肾上腺素或多巴胺的含量变化。结果 :头风胶囊高、中、低剂量能非常明显或明显升高大鼠脑组织中 5 羟色胺、多巴胺及去甲肾上腺素的含量 (P <0 .0 1或P <0 .0 5 )。结论 :结果提示 ,头风胶囊能对抗偏头痛发作时单胺类神经递质水平的失常 ,使机体单胺类神经递质的释放和代谢机制得以恢复 ,改善脑及血管的功能障碍 ,从而改善偏头痛症状。

Objective:To research the influence and mechanism of Toufeng capsule (TFC) on the concentratioin of blood active substance and single amine neurotransmitter in the brain and blood of magraine mice.Methods: We chose animal disease model of migraine made by hypodermic nitroglycerin and measured the concentration of 5 HT. NE and DA in the rat's brain and blood by means of enzymeimmunoassay experimental methods.Results: TFC could obviously increase the concentration of 5 HT and NE in the bloold and of 5 HT, DA and NE in the brain.Conclusions: TFC might improve neurosystematic regulation functions and enhance the neurotransmitters' secretion and metabolism.