应用ROC曲线分析评价果糖胺对糖尿病的诊断价值

Applycation of receiver operating characteristic curve to evaluate fructosamine effects on identification of diabetes mellitus

目的 探讨果糖胺 (FTA)对糖尿病 (DM)的诊断价值。方法 应用受试者特征 (ROC)曲线对 74例DM患者及 5 5例non -DM中老年人的FTA、空腹血糖 (FBG)及糖化血红蛋白 (GHbA1c)水平进行比较与分析。结果 ①DM组上述指标的平均水平均明显高于non -DM组 (P <0 0 1) ;②FTA、FBG和GHbA1c的ROC曲线下面积分别为 96 4%、94 3%、83 0 % ,对DM具有较高的诊断价值 ;③FTA似以 1 5mmol/L作为诊断参考值 ,其敏感性为 96 0 % ,特异性为81 8% ,准确性为 89 9% ,阳性预告值为 87 7% ,阴性预告值为 93 8% ,阳性似然比为 5 2 7;FBG以 7 0mmol/L为诊断参考值 ,其敏感性为 93 2 % ,特异性为 74 6 % ,准确性为 86 0 % ,阳性预告值为 83 1% ,阴性预告值为 89 1% ,阳性似然比为 3 6 7;GHbA1c以 4 92 %为诊断参考值 ,其敏感性为 96 0 % ,特异性为 36 4% ,准确性为 70 5 % ,阳性预告值为6 3 5 % ,阴性预告值为 87 0 % ,阳性似然比为 1 5 1。结论

Objective To study the diagnostic effects of Fructosamine (FTA)?FBG and GHbA1c towards diabetes mellitus. Methods By using the receiver operating characteristic (ROC) curve ,this essay evaluates the diagnostic effects of FTA?FBG and GHbA1c to 77case DM and 55 non-DM adult persons. Results ①The average levels of FTA?FBG and GHbA1c in DM group are higher than those in non-DM group(P<0.01).②The under-curve area of FTA ?FBG and GHbA1c are 96.4%?94.3%?83.0%,respectively.All show a satisfied diagnostic effect.③ It seems that the best cut-off point of FTA may be 1.5mmol/L which generates a sensitivity of 96.0% and a specificity of 81.8% and a accuracy of 89.9%and a positive predictive value of 87.7% and negetive predictive value of 93.8% and positive likelihood ratio of 5.27 .Conclusion FTA can make comments on Diabetic monitor.