米非司酮药物流产时绒毛膜及蜕膜组织的超微结构改变

Ultrastructural observation of the decidua and chorion during early pregnancy terminated by mifepristone

目的 探讨米非司酮药物流产时 ,绒毛膜及蜕膜的形态学变化。方法 应用光镜和透射电镜对 10例米非司酮药物流产患者 (观察组 )和 10例人工流产患者 (对照组 )在流产当时留取绒毛膜和蜕膜进行形态学观察。结果 观察组标本中绒毛膜和蜕膜组织细胞均表现出一种自噬性凋亡倾向。蜕膜组织中颗粒细胞内的分泌颗粒减少或消失 ,间质内网状纤维溶解、断裂。结论 米非司酮药物流产时 ,绒毛膜及蜕膜细胞均呈现一种自噬性凋亡倾向 ,同时释放大量松弛素 ,引起网状纤维溶解、断裂 ,蜕膜组织崩解。

Objective\ To observe the ultrastructural changes of chorion and decidua during termination of early pregnancy by mifepristone.Methods\ A total of 20 women who requested abortion was recruited,10 cases of artificial abortion(control group)and 10 medical abortion with mifepristone.For each women,the chorion and decidua were taken as soon as they shed.Specimens were observed by optical and electron microscopy.Results\ It showed that cells of chorion and decidua had autophagic apoptotic tendency.The granules of decidua granulocytes reduced or even disappeared,together with disintegration or even rupture of the reticular fibers.Conclusion\ The chorion and decidua have autophagic apoptotic tendency during termination of early pregnancy by mifepristone,together with disintegration of the reticular fibers.