不同时段选择性动脉溶栓治疗急性脑梗死的临床研究

Stady on Seletive intra-arterial thrombolytic therapy of different time course in patients with acute cerebral infarction

目的 探讨病程超过６ｈ的脑梗死动脉溶栓治疗的可行性。方法 ４４例脑梗死患者按病程分为Ａ组 （病程≤６ｈ）和Ｂ组（病程６～２４ｈ），两组均接受选择性动脉溶栓治疗。结果 对两组间的血管再通率、治疗前后神经 功能缺损积分差值、病后９０ｄ的巴氏指数、出血转化率和溶栓治疗中发生血管再通的时间进行比较，均无显著性差 异。结论 部分脑梗死患者选择性动脉溶栓治疗时间窗可以延长至６ｈ以后，且仍可以取得较高血管再通率和较好 的临床疗效。

Objective To investigate the practicability in patients with acute cerebral infarction after 6h of stroke onset who received intra-arterial thrombolytic therapy. Methods 44 cases were divided into two groups (A and B) according to course of time within 6h and from 6 to 24h of stroke onset for received intra-arterial thom- bolytic therapy. Results There were no significant differences in recanalization rate, clinical outcome, cerebral hemorrhage incidence and reperfusive time of occluded artery between A and B. Conclusion Part of the cases with cere bral infarction after 6h of stroke onset can benefit from intra-arterial thrombolytic therapy.