腹部外科SIRS患者下丘脑-垂体-甲状腺轴的功能改变及机制探讨

Study on Function of Hypothalamus-Pituitary-Thyroid Axis in Patients with SIRS

目的 :研究SIRS状态下下丘脑 -垂体 -甲状腺轴的功能改变并探讨其机制。 方法 :应用放射免疫分析方法测定 2 5例病人的血清T3 、T4、rT3 、TSH、TRH水平 ,并与 2 0例正常对照进行比较。 结果 :SIRS病人血清T3 、T4水平低于对照组 ,TSH和TRH水平观察组高于对照组。 结论 :SIRS病人下丘脑 -垂体 -甲状腺轴的功能出现紊乱 ,其可能的机制是由于甲状腺本身的功能受到抑制以及应激刺激作用的结果。

To study the function changes of hypothalamus-Pituitary-thyroid axix in SIRS Methods:Serum levels of T 3,T 4,rT 3,TSH and TRH were measured using RIA in 25 patients with abdominal surgical diseases with SIRS and in 20 healthy subjects.Results:The contents of serum T 3 and T 4 in patients with SIRS were less than those in healthy subjects;the contents of serum TSH,TRH in patients with SIRS were higher than those in the control.Conclusion:The function of hypothalamus-pituitary-thyroid axis changed significantly in patients with SIRS.