摘要
浅表性膀胱癌(T_1,Ta,Tis)术后易复发,尽管大多数复发的肿瘤与原发肿瘤的分级、分期相同,但5％—30％的肿瘤发展向深层浸润。因此对于易复发的病变,应该进行有选择的局部治疗。预防方法主要包括膀胱内化疗药物和免疫相关药物卡介苗及生物制剂的灌注及光动力学治疗。灌注化疗药物疗效相近,但不能阻止膀胱癌复发时出现病变进展;卡介苗是膀胱内灌注预防浅表性膀胱癌复发疗效最好的药物,可延缓肿瘤的进展;干扰素可作为BCG或化疗失败时的二线首选药物。光动力学有助于术后残余病变的发现,用于预防复发有待于进一步研究。
Superficial bladder cancer includes T1, Ta, Tis transitional cell carcinomas by the TNM classification. Transurethral resection remains the Standard for first-line treatment, but patients with superficial bladder cancer are at such high risk for recurrence that a variety of treatments have been employed as adjuvant therapy to prevent the recurrence and progression of the cancer. These include intravesical chemotherapy; intravesical immunotherapy with BCG, interferon and photodynamic therapy. All agents for ...
出处
《当代医学》
2001年第10期49-53,共5页
Contemporary Medicine
关键词
浅表性膀胱癌
预防
复发
手术后
superficial bladder cancer
prophylaxis
recurrence
