超选择动脉置泵灌注化学药物治疗晚期胃肠道癌

Super-selective intraarterial placement of pump and regional chemotherapy in the treatment of advanced gastrointestinal cancer

目的 评价术中超选择性动脉内置泵 ,术后区域灌注化疗对晚期胃肠道癌的疗效。方法 随访观察 79例手术证实不能切除的晚期胃肠道癌症患者 ,经超选择性动脉内置泵灌注化学药物的疗效。其中胃癌 42例 ,直肠癌 2 6例 ,结肠癌 11例。结果 化学药物治疗 (化疗 )后 ,完全缓解者 (CR) 1例 ;部分缓解者 (PR) 6 9例 ,其中 11例行二期根治性癌灶切除术。有效率 89%(70 / 79)。置泵术后生存满 1、2、3年者分别为 84%(6 6 / 79)、2 8%(2 2 / 79)、9%(7/ 79) ,平均生存期为 2 0 6个月。结论 术中超选择性动脉内置泵 ,术后泵内区域灌注化疗是治疗晚期胃肠道癌症的有效方法 ,可以延长患者的生存期 ,提高手术切除率。

Objective To evaluate the effect of intraoperative placement of super-selective intraarterial pump and postoperative regional infusion chemotherapeutics for the treatment of laparotomy proved inoperable advanced gastrointestinal cancer. Methods Intraoperatively the major artery supplying the tumor was identified and cannulated with the placement of a pump. Postoperative regional chemotherapy was carried out in 79 cases of gastrointestinal cancer. Among them there were 42 cases of gastric cancer, 37 of colorectal cancer. Results Complete tumor remission was achieved in 1 case, partial remission in 69 cases. This therapy also enabled second stage tumor resection in 11 cases. The total effective rate reached 88.6%. The 1-, 2-, and 3- years' survival rates were 84%,28% and 9%, respectively, averaging the survival period at 20.6 months. Conclusion Super-selective intraarterial pump-insertion and postoperative regional chemotherapy is effective in the treatment of advanced inoperable gastrointestinal cancer.