肺心病患者β-内啡肽与细胞免疫变化关系的研究

Study of the Relation Between β-endorphin and Cellular Immunity in Patients with Cor Pulmonale

同步检测了 36例肺心病急性加重期患者血浆 β -内啡肽 (β -EP)及外周血T淋巴细胞亚群变化。结果显示肺心病急性加重期患者血浆 β -EP明显升高 ,外周血CD3、CD4、CD8、CD4/CD8比值均显著下降 ,与缓解期及对照组相比具有显著差异 (P <0 .0 1)。直线相关分析显示 ,肺心病急性加重期血 β -EP分别与CD3、CD4及CD4/CD8比值呈显著负相关 (P <0 .0 1)。研究结果提示 ,肺心病急性加重期机体内存在着神经内分泌免疫调节紊乱 ,显著升高的血

Plasma levels of β-endorphin(β-EP) and the counts of CD3, CD4, CD8 cells and CD4:CD8 ratio of peripheral blood in 36 patients with cor-pulmonal during acute exacerbation were examined. The results showed that in case during acute exacerbation stage the plasma levels of β-EP were markedly increased and the counts of CD3?CD4?CD8 cells and the CD4:CD8 ratio in peripheral blood were remarkabl decreased ( P <0.01). Linear correlation analyses showed that β-EP was inversely correlated with CD3?CD4 cells counts and the CD4:CD8 ratio respectively ( P <0.01) during acute exacerbation stage. The study indicated the presence of disorder of neuroendocrinoimmunomodulation in cor pulmonal during acute exacerbation which expressed as significantly increased levels of β-EP inhibiting cellular immunity.