NMP 22在膀胱癌诊断中的应用

Nuclear matrix protein 22(NMP 22) for the diagnosis of transitional cell carcinoma of the bladder

目的 探讨尿液核基质蛋白 2 2 (NMP 2 2 )在膀胱移行细胞癌诊断中的意义。 方法 采用酶联免疫吸附实验 (NMP 2 2试剂盒 )测定 312例送检尿样的NMP 2 2值 ,并以膀胱镜检的病理报告为对照 ,统计其方法的灵敏度、特异性及准确性。 结果 尿NMP 2 2检测膀胱移行细胞癌灵敏度 71%、特异性 75 %、准确性 73%。 结论 尿NMP 2 2的检测 ,为一种无创伤、无痛苦、能早期诊断且灵敏度、特异性、准确性均较高的膀胱肿瘤临床诊断指标。

Objective To evaluate the urinary nuclear m atrix protein 22(NMP 22) as a marker for transitional cell carcinoma of the blad d er. Methods 312 urine samples of NMP 22 were analysis b y means of enzyme-linked immunosorbent assay(ELISA). Results The sensitivity of urinary NMP 22 in detection of transitional cell carcin o ma was 71%; the specificity 75% and the accuracy 73%. Conclusions NMP 22 is a promising urinary tumor marker for monitoring transitiona l cell carcinoma.The procedure is nontraumatic,sensitive and specific making earl y diagnosis feasible.