血管内皮生长因子和血管生成与大肠癌发展的关系

The relation of vascular endothelial growth factor and angiogenesis to the progression of colorectal carcinoma

目的 探讨血管内皮细胞生长因子 (VEGF)和血管生成与大肠癌发展的关系。方法 应用免疫组化法 ,检测 10 2例大肠癌组织VEGF蛋白表达和微血管密度 (MVD) ,分析VEGF和MVD及其与大肠癌组织学分级、浸润深度、Dukes分期、淋巴结转移、肝转移和预后的关系。结果 VEGF阳性者MVD值显著高于阴性者 (P <0 .0 1) ,VEGF表达和MVD与大肠癌Dukes分期、淋巴结转移和肝转移密切相关 (P均 <0 .0 1) ,VEGF表达阳性或高MVD的大肠癌患者 5年生存率较低 (P <0 .0 1)。结论 VEGF与大肠癌的血管生成密切相关 ,对大肠癌的生长和浸润转移有促进作用 。

Objective To investigate the relation of vascular endothelial growth factor (VEGF) and angiogenesis to the progression of colorectal carcinoma (CC). Methods VEGF protein expression and microvessel density (MVD) in 102 cases of human CC were examined by use of immunohistochemical staining. MVD and VEGF expression were analysed with their relation to histological grade, depth of invasion, Dukes stage, lymph node metastasis, liver metastasis and prognosis of CC. Results MVD was significantly higher in VEGF positive CC than in VEGF negative CC ( P <0.01). MVD and VEGF positively correlated with Dukes stage ( P <0.01), lymph node metastasis ( P <0.01) and liver metastasis ( P <0.01). The five year survival rate was significantly lower in CC patients with positive expression of VEGF or high MVD. Conclusion VEGF is highly related to angiogenesis of CC and promotes growth, invasion and metastasis of CC. VEGF expression or MVD is one of the important predictors of the biological behavior of CC.