肝硬化患者左旋氧氟沙星口服后腹水中浓度的检测

Study on the Concentration of Levofloxacin in ascites of Patient with Cirrhosis after oral administration

目的 研究左旋氧氟沙星口服后 ,在肝硬化患者腹水中的药物分布及动态变化。方法 收集 7例肝硬化合并腹水患者口服左旋氧氟沙星后 ,不同时间点的腹水标本 ,采用高效液相法 ,检测其中药物浓度并观察其动态变化。结果 口服 2h后 ,即可在腹水中检测到 ,并随时间推移而逐渐升高 ,腹水中达药物高峰时间 (T max )约 6 .0h ,腹水药物峰浓度 (C max )2 .5 2 0± 1.2 13μg·ml-1。此后逐渐下降 ,至 12h趋于稳定。结论 左旋氧氟沙星口服后 ,较短时间内在患者的腹水中有分布 ,并可形成高峰浓度 ,30 0mg口服后 ,腹水中有效药物浓度可持续时间长达

Aim To study the concentration of levofloxacin in the ascites of the patients with cirrhosis after the oral administration.Methods Concentration of levofloxacin in the ascites was detected with HPLC in seven patients with cirrhosis in different moment respectively.Results The concentration of levofloxacin depended on the duration time after the oral administration.T max is 6.0h and C max is 2.520±1.213μg·ml -1 .The levels decreased gradually after reaching peak concentration,then stabilized in 12h.Conclusion After the oral administration,levofloxacin can distribute in ascites and reach a peak.Effective concentration can last 12h and over.