格替沙星片溶出度测定条件的优选实验

Study of Selecting an Ideal Dissolution Determining Condition of Gatifloxacin Tablet

目的 优化格替沙星片的溶出度测定条件。方法 采用正交实验对该药片溶出度测定的基本条件 (转速、取样时间、溶出介质 )进行筛选 ,采用紫外分光光度法测定含量。结果 筛选出 80r/min ,45min取样 ,0 .1mol·L-1的盐酸作溶出介质为该药溶出度的最佳测定条件。结论 采用正交实验法筛选出的最佳溶出条件 ,快速、准确。

Aim To select an ideal dissolution determining condition of drug tablets.Methods An orthogonal design was used to select the conditions (rotational speed, sampling time and releasing media), determined by UV spectrophotometry.Results By using the orthogonal design we have got an ideal determining condition of the dissolution.Rotational speed is 80rpm,sampling time is 45min and releasing media is 0.1mol·L -1 hydrochloride.Conclusion The orthogonal design is an ideal tool in the selection of the conditions of the drug dissolution.it is rapid and accurate.