BVMAP方案治疗难治性非霍奇金淋巴瘤的临床研究

Clinical study on BVMAP regimen in the treatment of refractory non-Hodgkin′s lymphoma

目的 观察BVMAP方案治疗难治性非霍奇金淋巴瘤 (NHL)的疗效。方法 采用博莱霉素 10mg/m2 ,肌肉注射 ,第 1,3,5天 ;长春地辛 3mg/m2 ,静脉滴注 ,第 1,8天 ;氨甲喋呤 12 0mg/m2 ,静脉滴注 ,第 1,8天 ;阿糖胞苷 6 0mg/m2 ,静脉滴注 ,第 1～ 5天 ;强的松 (PDN) 30mg/m2 ,口服 ,第 1～ 14天。 2 8天为 1个周期 ,连续用药 2个周期以上评价疗效。结果 全组 30例 ,CR 5例 ,PR 13例 ,NC 10例 ,PD 2例 ,有效率 6 0 %。不良反应主要是白细胞和血小板下降 ,发生率分别为86 .7%和 6 0 .0 %。结论 BVMAP方案治疗难治性NHL疗效满意 ,毒副反应较低 ,安全可靠。

Objective To observe the effect of BVMAP regimen in treatment of refractory non-Hodgkin′s lymphoma.Methods BVMAP regimen:BLM 10mg/m 2,d1,3,5;VDS 3mg/m 2,d1,8;MTX 120mg/m 2,d1,8;Ara-C 60mg/m 2,d1～5;PDN 30mg/m 2,d1～14.Cycles repeated for 28 days.All the patients received over two cycles of chemotherapy.Results In all 30 patients,60% of response rate were achieved with 5 cases CR,13 cases PR,10 cases NC,2 cases PD.Main toxicities were neutropenia and thrombocytopenia with occurrence rate of 86.7% and 60.0% respectively.Conclusion BVMAP regimen in the treatment of refractory non-Hodgkin′s lymphoma is an active regimen with relatively low toxicity and well tolerance.