摘要
目的 :观察番茄红素对甲基戊基亚硝胺 (MANA)致癌性的影响。方法 :随机将Wistar大鼠分为 3组 :MANA组 (M )、MAN A +番茄酱组 (M +LP)和对照组 (C)。实验期为 2 6周 ,观察大鼠食管和胃粘膜病理变化 ,同时检测血清活性氧单位 (ROSu nit)、超氧化物歧化酶 (SOD)、丙二醛 (MDA)以及全血谷胱甘肽过氧化物酶 (GSH Px)水平。结果 :M组和M +LP组大鼠食管和前胃均发生癌前病变 ,而M +LP组大鼠癌前病变发生率低于M组 ;M +LP组大鼠血中ROSunit、SOD、GSH Px活性较M组高 ,MDA含量较M组低。结论 :番茄红素具有抑制MANA致癌的作用 。
Purpose: To study the effects of lycopene on the carcinogenicity of N methyl N amylnitrosamine(MANA) in Wistar rats. Methods: The rats were randomly divided into three groups: simple MANA (M), MANA plus tomato jam (M+LP) and control(C) groups. The experiment lasted 26 weeks. Histological \{examination\} was done and the levels of ROS unit, SOD, GSH Px and MDA in the blood were determined. Results: There were precancerous lesions of esophagus or forestomach in the M and M+LP groups. The incidence of precancerous lesions in the M+LP group was decreased, and the levels of ROS unit, SOD, GSH Px in the blood were higher, but the content of MDA was decreased. Conclusion: Lycopene may have an inhibitory effect on the carcinogenicity of MANA. The effect may be due to the inhibition of lipid peroxidation.
出处
《癌变.畸变.突变》
CAS
CSCD
2001年第3期151-154,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
广东省医药卫生青年科学研究基金资助!(B2 0 0 0 0 94)
关键词
亚硝胺
食管癌
番茄红素
nitrosamine
esophageal cancer
lycopene
Wistar rat