Ⅱ期老年高血压病患者血管内皮功能与氧化低密度脂蛋白结果分析

Relationship between the functions of Vascular Endothelial cell and the changes of OX-LDL of elder hypertension

目的通过老年高血压患者血管内皮功能与氧化低密底脂蛋白变化分析 ,探讨老年高血压病发生发展机理 ,寻求较好的治疗方法。方法本研究按WHO高血压诊断标准 ,选择年龄为 6 0～72岁Ⅱ期的老年高血压患者 6 0例 ,与 30例正常健康者进行对照 ,比较两组的一般特点 ,同时检测氧化低密度脂蛋白 (OX—LDL)、内皮依赖舒张因子 (NO) ,血管内皮素 (ET) ,血管内皮细胞计数 (CEC)。结果两组结果显示 ,正常对照组与高血压组在年龄 ,性别组成方面差异无显著性 ,但两组的血压比较则差异有显著性 (P <0 0 0 1) ,高血压组的OX—LDL、ET、CEC结果均高于正常对照组 ,NO结果则低于正常对照组。结论上述结果变化与Ⅱ期老年高血压发生发展有一定关系 ,提示在临床治疗中不仅要注重血管内皮功能保护 ,同时应加强抗氧化治疗 ,延缓高血压发展。

Objective To study the mechanism of elder hypertension. Methods The healthy people were used as normal group, hypertension were used as control group. The common characteristic and OX-LDL, No, ET, CEC were compared and determined. Results The BP, ET, CEC, OX-LDL and weight index of control group were higher than normal group. The level of NO of control group was lower. Conclusion It is suggested that protection the function of endothelial cells and treated hypertension with anti-oxygenate drug, which maybe an important mechanism.