醋氨己酸锌治疗肝硬化合并消化性溃疡

Zine acexamate in treatment of cirrhosis of liver complicated peptic ulcer

目的 :观察醋氨己酸锌对肝硬化合并消化性溃疡的疗效。方法 :肝硬化合并十二指肠溃疡 36例和合并胃溃疡 30例 ,随机分为醋氨己酸锌组 (醋氨己锌 0 .3g ,po ,tid ,其中胃溃疡 12例、十二指肠溃疡 12例 )、法莫替丁组 (法莫替丁 2 0mg ,po ,bid ,其中胃溃汤 9例、十二指肠溃疡 10例 )、联合用药组 (醋氨己酸锌 0 .3g ,po ,tid ,法莫替丁 2 0mg ,po ,bid ,其中胃溃疡 9例、十二指肠溃疡 14例 ) ,共3组。治疗胃溃疡疗程 6wk ,十二指肠溃疡疗程为4wk ,疗程结束后 ,用内窥镜观察溃疡愈合情况。结果 :醋氨己酸锌组肝硬化合并胃溃疡和十二肠溃疡的愈合率分别为 5 8% ,6 6 % ,法莫替丁组分别为5 6 % ,70 % ,联合用药组分别为 78% ,79% ,3组比较差异无显著意义 ,P >0 .0 5。结论 :醋氨己酸锌治疗肝硬化合并消化性溃疡的疗效与其他 2组相似 。

AIM: To observe the effect of zinc acexamate for cirrhosis of the liver complicated peptic ulcer METHODS: Sixty six patients with cirrhosis of the liver complicated peptic ulcer (36 complicated duodenal ulcer and 30 complicated gastric ulcer) were randomly divided into three groups. Zinc acexamate group (12 with gastric ulcer and 12 with duodenal ulcer) was treated with zinc acexamate 0.3, po , tid. Famotidine group (9 with gastric ulcer and 10 with duodenal ulcer) was treated with famotidine 20 mg, po , bid. And united treatment group (9 with gastric ulcer and 14 with duodenal ulcer) was treated with zinc acexamate 0.3 g, po , tid and at the same time with famotidine 20 mg, po , bid. The period of treatment to gastric ulcer was 6 wk and to duodenal ulcer was 4 wk. The curative effect was observed by endoscopy after treatment. RESULTS: The cure rate of gastric ulcer and duodenal ulcer in zinc acexamate group were 58% and 66% respectively, in famotidine group were 56% and 70% respectively, in united treatment group were 78% and 79% respectively. There was no statistical difference of the curative effect in three groups ( P >0.05). CONCLUSION: Zinc acexamate was effective and safe in treating the patients with cirrhosis of the liver complicated peptic ulcer.